From: <Enregistré par Microsoft Internet Explorer 5>
Subject: ARD -- Instructions to Authors
Date: Sun, 7 Dec 2003 09:01:38 -0000
MIME-Version: 1.0
Content-Type: multipart/related;
	boundary="----=_NextPart_000_007F_01C3BCA0.B96D1970";
	type="text/html"
X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2800.1106

This is a multi-part message in MIME format.

------=_NextPart_000_007F_01C3BCA0.B96D1970
Content-Type: text/html;
	charset="Windows-1252"
Content-Transfer-Encoding: quoted-printable
Content-Location: http://ard.bmjjournals.com/misc/ifora.shtml

<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML><HEAD><TITLE>ARD -- Instructions to Authors</TITLE>
<META http-equiv=3DContent-Type content=3D"text/html; =
charset=3Dwindows-1252">
<META content=3D"MSHTML 6.00.2800.1106" name=3DGENERATOR></HEAD>
<BODY bgColor=3D#ffffff>
<TABLE cellSpacing=3D0 cellPadding=3D0 border=3D0>
  <TBODY>
  <TR>
    <TD vAlign=3Dbottom noWrap><A style=3D"TEXT-DECORATION: none"=20
      href=3D"http://ard.bmjjournals.com/" target=3D_top><IMG =
height=3D44=20
      alt=3D"Ann Rheum Dis"=20
      src=3D"http://ard.bmjjournals.com/icons/banner/title.gif" =
width=3D220=20
      border=3D0></A> <A=20
      =
href=3D"http://ard.bmjjournals.com/cgi/adclick?journal=3Dannrheumdis&amp;=
ad=3DMP%20%32%30%30%33&amp;url=3Dhttp://mp.bmjjournals.com&amp;side=3Donl=
y"=20
      target=3D_top><IMG height=3D40 alt=3D"Molecular Pathology"=20
      src=3D"http://ard.bmjjournals.com/adgifs/1045585937.gif" =
width=3D220=20
      border=3D2></A> <BR><IMG height=3D3 alt=3D""=20
      src=3D"http://ard.bmjjournals.com/icons/spacer.gif" width=3D1><BR>
      <TABLE cellSpacing=3D2 cellPadding=3D2 width=3D450>
        <TBODY>
        <TR>
          <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
            style=3D"TEXT-DECORATION: none" =
href=3D"http://ard.bmjjournals.com/"=20
            target=3D_top><FONT face=3Darial,helvetica color=3D#ffffff=20
            size=3D-2>HOME</FONT></A></TD>
          <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
            style=3D"TEXT-DECORATION: none"=20
            href=3D"http://ard.bmjjournals.com/help/" =
target=3D_top><FONT=20
            face=3Darial,helvetica color=3D#ffffff =
size=3D-2>HELP</FONT></A></FONT></TD>
          <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
            style=3D"TEXT-DECORATION: none"=20
            href=3D"http://ard.bmjjournals.com/cgi/feedback" =
target=3D_top><FONT=20
            face=3Darial,helvetica color=3D#ffffff =
size=3D-2>FEEDBACK</FONT></A></TD>
          <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
            style=3D"TEXT-DECORATION: none"=20
            href=3D"http://ard.bmjjournals.com/subscriptions/" =
target=3D_top><FONT=20
            face=3Darial,helvetica color=3D#ffffff=20
          size=3D-2>SUBSCRIPTIONS</FONT></A></TD>
          <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
            style=3D"TEXT-DECORATION: none"=20
            href=3D"http://ard.bmjjournals.com/contents-by-date.0.shtml" =

            target=3D_top><FONT face=3Darial,helvetica color=3D#ffffff=20
            size=3D-2>ARCHIVE</FONT></A></TD>
          <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
            style=3D"TEXT-DECORATION: none"=20
            href=3D"http://ard.bmjjournals.com/search.dtl" =
target=3D_top><FONT=20
            face=3Darial,helvetica color=3D#ffffff =
size=3D-2>SEARCH</FONT></A></TD>
          <TD noWrap width=3D75></TD></TR></TBODY></TABLE></TD>
    <TD><IMG height=3D5 alt=3D"" =
src=3D"http://ard.bmjjournals.com/icons/spacer.gif"=20
      width=3D5></TD>
    <TD vAlign=3Dbottom><IMG height=3D5 alt=3D""=20
      src=3D"http://ard.bmjjournals.com/icons/spacer.gif" =
width=3D5></TD></TR>
  <TR>
    <TD colSpan=3D3>
      <HR align=3Dleft color=3D#000000 noShade SIZE=3D1>
    </TD></TR></TBODY></TABLE><FONT face=3Dverdana,arial,helvetica=20
size=3D-2><NOBR><STRONG>Institution: Morocco:BMJ-PG =
Sponsored</STRONG></NOBR>=20
<NOBR><A =
href=3D"http://ard.bmjjournals.com/cgi/login?uri=3D%2Fmisc%2Fifora.shtml"=
=20
target=3D_top>Sign In as Member/Non-Member</A></NOBR> </FONT><!-- =
showauthstring --><!-- INST --><!-- INDV --><!-- SPONSORED --><!-- =
USER.PFA --><!-- USER.PFABSAIC --><!-- NOT GUEST -->
<HR align=3Dleft width=3D446 noShade>
<!-- DO NOT EDIT ANYTHING ABOVE THIS LINE -->
<P><FONT face=3DArial size=3D2><A=20
href=3D"http://ard.bmjjournals.com/misc/about.shtml">About ARD</A> | <A=20
href=3D"http://ard.bmjjournals.com/misc/edboard.shtml">Editorial =
board</A> | <A=20
href=3D"http://ard.bmjjournals.com/misc/reprint.shtml">Reprints</A></FONT=
>=20
<P><FONT face=3DArial color=3D#9a1149 size=3D5><B>How to submit your =
manuscript to=20
ARD</B></FONT>=20
<P><I><FONT face=3DArial size=3D2>(updated 1st August 2003)</FONT></I>
<P><B><FONT face=3DArial size=3D2>For details on how to submit your =
manuscript=20
online, via Bench&gt;Press, <A=20
href=3D"http://ard.bmjjournals.com/misc/ifora.shtml#bp">click =
here</A></FONT></B>
<P><B><FONT face=3DArial size=3D2>For manuscript formatting guidelines =
please read=20
below.</FONT></B>=20
<P>
<HR>

<P><FONT face=3DArial size=3D2><B>Editorial Office</B>=20
<P>Professor Leo van de Putte<BR><I>Annals of the Rheumatic=20
Diseases</I><BR>University Medical Centre Nijmegen<BR>Department of=20
Rheumatology<BR>PO BOX 9101<BR>6500 HB Nijmegen<BR>The =
Netherlands</FONT>=20
<P><FONT face=3DArial size=3D2>ALL manuscripts should now be submitted =
via <A=20
href=3D"http://submit-ard.bmjjournals.com/"><B>Bench&gt;Press</B></A>.
<P>However, if you are unable to do so, please send the manuscript=20
electronically via email (<A=20
href=3D"mailto:annrheumdis.edoff@worldonline.nl">annrheumdis.edoff@worldo=
nline.nl</A>)=20
or on a floppy disk to the Editorial Office. Manuscripts should be typed =
in=20
double line space and paginated, with the name, postal and e-mail =
address of a=20
corresponding author clearly marked on the title page. </FONT>
<P><FONT face=3DArial size=3D2>The Editorial Office (address as above) =
will help you=20
with any enquiries about the journal's requirements.<BR>Tel: +31 24 361=20
9851<BR>Fax: +31 24 361 9850<BR>Email: <A=20
href=3D"mailto:annrheumdis.edoff@worldonline.nl">annrheumdis.edoff@worldo=
nline.nl</A></FONT>=20

<P>
<HR>

<P>
<H1></A><B><FONT face=3DArial color=3D#9a1149 size=3D4>General=20
Information</FONT></B></H1>
<P><FONT face=3DArial size=3D2>The <EM>Annals</EM> publishes original =
work on all=20
aspects of rheumatology and disorders of connective tissue. Laboratory =
and=20
clinical studies are equally welcome.</FONT>=20
<P><FONT face=3DArial size=3D2>Submissions are accepted only on the =
understanding=20
that they have not been submitted elsewhere and have not been and will =
not be=20
published elsewhere (either in part or in whole) and are subject to =
editorial=20
revision.</FONT>=20
<P><FONT face=3DArial size=3D2>Authors must declare and submit copies of =
any=20
manuscripts in preparation or submitted elsewhere that are closely =
related to=20
the manuscript to be considered. These can be uploaded as supplementary =
files on=20
Bench&gt;Press.</FONT>=20
<P><STRONG><FONT face=3DArial size=3D2>You may suggest suitable =
reviewers (with full=20
mailing addresses, contact numbers, and email addresses) for your=20
paper.</FONT></STRONG>
<P><FONT face=3DArial size=3D2>We encourage authors to send copies of =
any previous=20
referees' reports on their research and indicate how these comments have =
helped=20
the authors to improve the submitted paper. This may be helpful to our =
editors=20
and reviewers. Please upload these as supplementary files on=20
Bench&gt;Press.</FONT>
<P><FONT face=3DArial size=3D2>Authors must conform to the uniform =
requirements for=20
manuscripts submitted to biomedical journals (<EM>BMJ</EM> =
1991;302:338-41).=20
Randomised controlled trials should be presented in a manner and format=20
consistent with the <A =
href=3D"http://www.consort-statement.org/">Revised CONSORT=20
statement</A> published in <I>JAMA</I> (2001;<B>285</B>:1987-91).</FONT> =

<P><FONT face=3DArial size=3D2>Manuscripts that do not conform to the =
following=20
instructions may be returned for modification before being =
reviewed.</FONT>=20
<P> <BR>
<H1><A name=3Dgen></A><B><FONT face=3DArial color=3D#9a1149 =
size=3D4>Formatting=20
guidelines</FONT></B></H1>
<P><FONT face=3DArial size=3D2><A=20
href=3D"http://ard.bmjjournals.com/misc/ifora.shtml#bp">Back to =
Guidelines for=20
Bench&gt;Press</A>=20
<P><FONT face=3DArial size=3D2>All submissions must be typed with double =
line=20
spacing. All abbreviations must be defined.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Title sheet=20
</FONT></B><BR>Stating the title of the paper, the category submitted =
(extended=20
report, concise report, etc), the authors, their affiliations (one =
department=20
and institution each), and the name and postal address (+ Tel/Fax/Email =
numbers)=20
of the corresponding author.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Extended=20
reports</B></FONT><BR>These represent a substantial body of laboratory =
or=20
clinical work. The study should be presented in sections - =
namely:</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Abstract =
</B></FONT><BR>No=20
more than 250 words, summarising the problem being considered, how the =
study was=20
performed, the salient results and the principal conclusions under =
subheadings=20
'Objectives', 'Methods', 'Results', and 'Conclusions'.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Key Words =
(maximum of=20
5)</FONT></B><BR>These should be given beneath the Abstract and in the =
box=20
provided in the online submission process.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Introduction=20
</FONT></B><BR>Brief description of the background that led to the study =

(current results and conclusions should not be included).</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT =
color=3D#9a1149>Methods</FONT></B><BR>Details=20
relevant to the conduct of the study. Wherever possible give numbers of =
subjects=20
studied (not percentages alone). Statistical methods should be clearly =
explained=20
at the end of this section.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Results =
</FONT></B><BR>Work=20
should be reported in SI units. Undue repetition in text and tables =
should be=20
avoided. Comment on validity and significance of results is appropriate =
but=20
broader discussion of their implication is restricted to the next=20
section.</FONT>=20
<P><FONT face=3DArial size=3D2>Subheadings that aid clarity of =
presentation within=20
this and the previous section are encouraged.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Discussion =
</FONT></B><BR>The=20
nature and findings of the study are placed in context of other relevant =

published data. Caveats to the study should be discussed. Avoid undue=20
extrapolation from the study topic.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Acknowledgments =
and=20
affiliations </FONT></B><BR>Individuals with direct involvement in the =
study but=20
not included in authorship may be acknowledged. The source of financial =
support=20
and industry affiliations of all those involved must be stated.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>References =
</FONT></B><BR>In=20
accordance with the Vancouver agreement these are cited by the numerical =
system=20
and listed in the order cited in the text, not in alphabetical order by =
authors'=20
names. (In the text, each reference number should be in square brackets =
on the=20
line.) List first six authors and then <EM>et al</EM> if appropriate. =
Journal=20
titles are abbreviated in accordance with the style of Index Medicus. =
See=20
references in the journal. Information from manuscripts not yet in =
press, papers=20
reported at meetings or personal communications should be cited in the =
text, not=20
as formal references. Responsibility for the accuracy and completeness =
of the=20
references lies with the author.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Tables =
</FONT></B><BR><FONT=20
face=3DArial size=3D2>Tables should be submitted in the same format as =
your article=20
and embedded in the article.<BR><BR><B><FONT color=3D#ff0000>Please=20
note:</FONT></B> Bench&gt;Press <B>CANNOT</B> accept Excel files. If =
your=20
table(s) are in Excel, copy and paste them into the manuscript file =
(where cited=20
is preferable).&nbsp; In extreme circumstances, Excel files can be =
uploaded as=20
supplementary files; however, we advise against this as this will not be =

acceptable if your article is accepted for publication.<BR><BR>Tables =
should be=20
self-explanatory, and the data they contain must not be duplicated in =
the text=20
or figures.<BR></FONT></P>
<P><FONT face=3DArial size=3D2><B><FONT =
color=3D#9a1149>Figures</FONT></B><BR>Legends=20
should be listed on a separate page. For photomicrographs include the =
stain=20
used: magnification should be indicated by a bar marker on the figure. =
If=20
appropriate, coloured illustrations may be published but part of the =
cost is=20
charged to the author.</FONT>
<P>
<P><FONT face=3DArial size=3D2><B>Black and white images</B><BR>Black =
and white=20
images (photographs, line drawings, graphs etc.) should be saved and =
supplied=20
as:<BR>TIFF, GIF, or high quality JPEG files to a minimum of 300 =
dpi.</FONT></P>
<P><FONT face=3DArial size=3D2><B>Colour images<BR></B>Colour images =
should be saved=20
and supplied as:<BR>TIFF, GIF, or high quality JPEG files to a minimum =
of 600=20
dpi.<BR>Colour images should not exceed 2MB at a minimum resolution of =
600 dpi.=20
If you choose a higher resolution your image dimension should be reduced =

accordingly to keep the file under 2MB.<BR><B>NB</B> Scanners may =
automatically=20
increase image size at a higher resolution.</FONT>=20
<P><FONT face=3DArial size=3D2><B>Powerpoint files</B><BR>SINGLE PAGE =
Powerpoint=20
files can be submitted.&nbsp; Please submit ONE slide per file =
ONLY.&nbsp;=20
<BR>Alternatively Powerpoint files can be saved as JPEG or TIFF files =
and=20
submitted as a single image file.<BR>&nbsp;<BR><B>ALL IMAGES SHOULD BE =
SUBMITTED=20
TO BENCH&gt;PRESS AS <FONT color=3D#ff0000>SEPARATE FILES</FONT> AND =
<BR><FONT=20
color=3D#ff0000>NOT</FONT> EMBEDDED IN THE MANUSCRIPT TEXT.</B></FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Concise=20
reports</FONT></B><BR>A brief communication presenting laboratory or =
clinical=20
work, collected case reports or, exceptionally, single case reports. The =
format=20
is identical to that of an Extended Report (see above) and should =
include an=20
Abstract, Keywords, Introduction, Methods, Results and Discussion (for =
cases,=20
'Case Reports' will substitute for Methods and Results). Concise reports =
are=20
restricted to no more than 1500 words, 15 references, one table, and two =

figures.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Hypothesis=20
article</FONT></B><BR>Contributions which present an interesting theory, =

discussed in relation to published data, are welcome. It is suggested =
that=20
authors first discuss the subject and scope of their planned article =
directly=20
with the Editor.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Review=20
article</FONT></B><BR>Although these are usually commissioned, authors =
are=20
invited to discuss directly with the Editor possible topics for =
review.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Lesson of the=20
month</FONT></B><BR>Real case histories that illustrate important =
clinical=20
lessons are divided into Case History and Discussion, with clear =
delineation of=20
'the lesson'. Lesson of the month is restricted to no more than 800 =
words, one=20
figure and one table.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Letters to the=20
Editor</FONT></B><BR>Comments arising from recent articles published in =
the=20
<EM>Annals</EM> are welcomed and will appear in the section Matters =
Arising.=20
Original observations relating to short clinical or laboratory studies =
or case=20
reports may also be appropriately presented as a Letter to the Editor. =
Letters=20
are not divided into sections and are limited to no more than 600 words =
and 10=20
references; one table and one figure may be included.</FONT>=20
<P><FONT face=3DArial size=3D2>Instructions for references, tables, and =
figures are=20
the same as for full length articles.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT=20
color=3D#9a1149>Proofs</FONT></B><BR>Contributors will receive one proof =
to be=20
read carefully for printer's errors.<BR>Alterations to the original text =
should=20
be kept to a minimum and may be charged to the author.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT =
color=3D#9a1149>Reprints</FONT></B><BR>These=20
may be ordered when the proofs are returned.</FONT>=20
<P><FONT face=3DArial size=3D2><B><FONT color=3D#9a1149>Commercial=20
reprints</FONT></B><BR>Contact Nadia Gurney-Randall:<BR></FONT><BR><FONT =

face=3DArial size=3D2>Tel: +44 (0)20 8346 1339<BR>Fax: +44 (0)20 8371 =
9314</FONT>=20
<P>
<HR>

<P><B><FONT face=3DArial color=3D#006699 size=3D5><A =
name=3Dbp></A></FONT><FONT=20
face=3DArial color=3D#9a1149 size=3D5><A name=3Dbench>Online</A> =
submission using <I><A=20
href=3D"http://submit-ard.bmjjournals.com/">Bench&gt;Press</A></I></FONT>=
</P>
<P><FONT face=3DArial color=3D#999999 size=3D2>Please =
note</FONT></B><FONT face=3DArial=20
color=3D#999999 size=3D2>: the following instructions apply to =
submission via=20
<I>Bench&gt;Press</I> <B>only. Manuscripts must still adhere to the =
standard=20
layout guidelines <A=20
href=3D"http://ard.bmjjournals.com/misc/ifora.shtml#gen">above</A></B>.</=
FONT></P><B>
<P><FONT face=3DArial color=3D#9a1149>Registering with <I>Bench&gt;Press =

</I></FONT></P></B>
<P><FONT face=3DArial size=3D2>Users are required to register with the =
system when=20
accessing the system for the first time. Click on =91CREATE A NEW =
ACCOUNT=92. You=20
will be asked to complete 3 steps: </FONT></P>
<P><B><FONT face=3DArial color=3D#999999 size=3D2>1.&nbsp;&nbsp;&nbsp;=20
Email/Password:<BR></FONT></B><FONT face=3DArial size=3D2><I><B>Enter =
your email=20
address:</B></I> This is your unique user identification and will be =
needed to=20
log into the system on ALL occasions.<BR><I><B>Enter a password:</B></I> =
This=20
will be encrypted for security reasons, and will not be known to either =
the ARD=20
editorial office or HighWire Press. If you forget your password you will =
need to=20
click on =91I HAVE FORGOTTEN MY PASSWORD=92 and follow the steps=20
outlined.&nbsp;<BR><I><B>Choose a =91password hint=92 question and =
provide an=20
answer:</B></I> You will need to provide this answer if you forget your=20
password. </FONT><B></P>
<P><FONT face=3DArial color=3D#9a1149 size=3D2>Please note: =
</FONT></B><FONT=20
face=3DArial size=3D2>a single password will be created which applies to =
ALL=20
journals using the <I>Bench&gt;Press</I> online submission and tracking =
system.=20
Once you have registered for your first journal, you do not need to =
re-register=20
in order to use another journal's system. Simply log in with your =
existing email=20
address and password. </FONT></P><B><FONT face=3DArial color=3D#999999=20
size=3D2>2.&nbsp;&nbsp;&nbsp; Verification:<BR></FONT></B><FONT =
face=3DArial=20
size=3D2>An email containing an URL will be emailed to you. Click on the =
URL. You=20
email address will then be verified. This helps ensure that your email =
address=20
is not being used fraudulently.</FONT>=20
<P><B><FONT face=3DArial color=3D#999999 size=3D2>3.&nbsp;&nbsp;&nbsp;=20
Profile:<BR></FONT></B><FONT face=3DArial size=3D2>You will then be =
asked to provide=20
a basic profile consisting of your contact information, plus expertise =
terms.=20
Although you may use the same e-mail address and password to access any =
journal=20
using the <I>Bench&gt;Press</I> system, you must create an individual =
profile=20
with each journal.</FONT></P><FONT face=3D"Arial Narrow" size=3D2>
<P> </P></FONT><B>
<P><A name=3Dsub><FONT face=3DArial color=3D#9a1149>Submitting a=20
manuscript</FONT></A></P></B>
<P><FONT face=3DArial size=3D2>To submit a manuscript enter the author =
area and=20
click on the "SUBMIT A NEW MANUSCRIPT" hyperlink. You will be presented =
with a=20
series of fields for entering your manuscript metadata and the uploading =
of your=20
text and figure files. Supplemental data can also be uploaded. The =
system will=20
automatically convert your files to a single PDF for reviewing purposes. =
You=20
will be asked to approve the conversion before it is considered formally =

submitted to the journal. The conversion process can take up to a =
maximum of 15=20
minutes; an email will be sent informing you when the conversion is =
complete.=20
Click on =91SUBMISSIONS READY FOR YOU TO PROOF=92 in the Author area to =
approve your=20
article. During conversion the system will automatically hyperlink the=20
references to Medline and/or the journal the article was published in =
(if the=20
journal is hosted on the web by HighWire Press). Please ensure you =
include the=20
heading "References" at the top of the citations for optimum linkage.=20
</FONT></P>
<P><FONT face=3DArial size=3D2>You are able to start your submission and =
continue=20
the process on another occasion. By clicking on =91SAVE/CONTINUE=92 at =
the bottom of=20
the screen when entering your metadata enables you to save that page or =
continue=20
to the next page. If you choose not to complete the submission on that =
occasion,=20
the submission will appear in the =91SUBMISSIONS IN PROGRESS=92 queue in =
the Author=20
area. If you decide not to complete the submission at all please choose=20
=91WITHDRAW=92. </FONT></P><B>
<P><FONT face=3DArial color=3D#999999 size=3D2>Please note:</FONT> </P>
<OL></B>
  <LI><FONT face=3DArial size=3D2>Do <B>not</B> include the cover letter =
in the body=20
  of the manuscript. This needs to be copied/pasted into the field =
available.=20
  </FONT>
  <LI><FONT face=3DArial size=3D2>If your paper does not include an =
abstract, please=20
  include the first paragraph of your article in the Abstract field. =
</FONT>
  <LI><FONT face=3DArial size=3D2>Supplemental files for upload may =
include:=20
  articles published/in press elsewhere; supplemental data; =
questionnaires,=20
  videos etc. </FONT>
  <LI><FONT face=3DArial size=3D2>Detailed help files are available =
throughout the=20
  process on <I>Bench&gt;Press</I>. </FONT></LI></OL><B>
<P><FONT face=3DArial color=3D#999999 size=3D2>File =
formats</FONT></B><BR><FONT=20
face=3DArial size=3D2>Papers can be submitted in any standard word =
processing=20
software, although Word is preferred.</FONT></P>
<P><FONT face=3DArial color=3D#9a1149><B>Figures</B></FONT></A><BR><FONT =
face=3DArial=20
size=3D2><B>Black and white images</B><BR>Black and white images =
(photographs,=20
line drawings, graphs etc.) should be saved and supplied as:<BR>TIFF, =
GIF, or=20
high quality JPEG files to a minimum of 300 dpi.</FONT></P>
<P><FONT face=3DArial size=3D2><B>Colour images<BR></B>Colour images =
should be saved=20
and supplied as:<BR>TIFF, GIF, or high quality JPEG files to a minimum =
of 600=20
dpi.<BR>Colour images should not exceed 2MB at a minimum resolution of =
600 dpi.=20
If you choose a higher resolution your image dimension should be reduced =

accordingly to keep the file under 2MB.<BR><B>NB</B> Scanners may =
automatically=20
increase image size at a higher resolution.</FONT>=20
<P><FONT face=3DArial size=3D2><B>Powerpoint files</B><BR>SINGLE PAGE =
Powerpoint=20
files can be submitted.&nbsp; Please submit ONE slide per file =
ONLY.&nbsp;=20
<BR>Alternatively Powerpoint files can be saved as JPEG or TIFF files =
and=20
submitted as a single image file.<BR>&nbsp;<BR><B>ALL IMAGES SHOULD BE =
SUBMITTED=20
TO BENCH&gt;PRESS AS <FONT color=3D#ff0000>SEPARATE FILES</FONT> AND =
<BR><FONT=20
color=3D#ff0000>NOT</FONT> EMBEDDED IN THE MANUSCRIPT TEXT.</B></FONT>=20
<P>
<P><FONT face=3DArial color=3D#9a1149><B>Tables</B></FONT></A><BR><FONT =
face=3DArial=20
size=3D2>Tables should be submitted in the same format as your article =
and=20
embedded in the article.<BR><BR><B><FONT color=3D#ff0000>Please =
note:</FONT></B>=20
Bench&gt;Press <B>CANNOT</B> accept Excel files. If your table(s) are in =
Excel,=20
copy and paste them into the manuscript file (where cited is =
preferable).&nbsp;=20
In extreme circumstances, Excel files can be uploaded as supplementary =
files;=20
however, we advise against this as this will not be acceptable if your =
article=20
is accepted for publication.<BR><BR>Tables should be self-explanatory, =
and the=20
data they contain must not be duplicated in the text or =
figures.<BR></FONT>
<P><FONT face=3D"Arial Narrow" size=3D2>
<P></P></FONT><B>
<P><FONT face=3DArial color=3D#9a1149>Submitting a =
revision</FONT></P></B>
<P><FONT face=3DArial size=3D2>To submit a revision enter the author =
area and click=20
on =91SUBMIT A REVISION/RESUBMISSION=92. You will be presented with your =
original=20
manuscript metadata. This can be edited where necessary. You will then =
be=20
required to upload your revised manuscript files (see <B>Submitting a =
Manuscript=20
</B>for further details). Please include your response to the reviewers' =

comments in the available field. If this is not entered your paper may =
be=20
returned to you.</FONT></P><B>
<P><FONT face=3DArial color=3D#9a1149>Miscellaneous</FONT></P></B>
<UL>
  <LI><FONT face=3DArial size=3D2>You can keep track of the status of =
your=20
  manuscript throughout the peer review process. Enter the Author area =
and click=20
  on =91MANUSCRIPTS UNDER REVIEW (CHECK STATUS)=92. </FONT>
  <LI><FONT face=3DArial size=3D2>Any reviewers=92 comments on your =
article will be=20
  found in the Author area. Enter =91MANUSCRIPTS WITH DECISIONS=92 and =
click on=20
  =91REVIEWS=92. This will link you direct to any comment on your paper. =
</FONT>
  <LI><FONT face=3DArial size=3D2>An invitation to write an article for =
the journal=20
  will also be requested via the online tracking system. Enter the =
Author area=20
  and click on =91REQUESTED COMMISSIONS=92. You can accept or decline =
the invitation=20
  online. When submitting your commissioned article, click on =
=91ACCEPTED=20
  COMMISSIONS =96 PAPERS TO BE SUBMITTED=92. The procedure for =
submission is the=20
  same as an unsolicited article (see <B><A=20
  href=3D"http://ard.bmjjournals.com/misc/ifora.shtml#sub">Submitting a=20
  Manuscript</A></B>). </FONT></LI></UL><B>
<P><FONT face=3DArial color=3D#9a1149>Help</FONT></P></B>
<P><FONT face=3DArial><FONT size=3D2>Detailed help files are available =
throughout=20
<I>Bench&gt;Press </I>and can be used without stopping the submission=20
process<I>. </I>If you experience serious problems you contact the ARD =
editorial=20
office: <A=20
href=3D"mailto:annrheumdis.edoff@bmjgroup.com">annrheumdis.edoff</A></FON=
T><A=20
href=3D"mailto:archdischild@bmjgroup.com"><FONT=20
size=3D2>@bmjgroup.com</FONT></A><FONT face=3DArial size=3D2>, or =
Natalie Davies,=20
Project Manager, </FONT><A href=3D"mailto:ndavies@bmjgroup.com"><FONT=20
size=3D2>ndavies@bmjgroup.com</FONT></A>=20
<P><FONT size=3D2><A =
href=3D"http://ard.bmjjournals.com/misc/about.shtml">About=20
ARD</A> | <A =
href=3D"http://ard.bmjjournals.com/misc/edboard.shtml">Editorial=20
board</A> | <A=20
href=3D"http://ard.bmjjournals.com/misc/reprint.shtml">Reprints</A></FONT=
></FONT> <!-- DO NOT EDIT ANYTHING BELOW THIS LINE -->
<P>
<HR align=3Dleft width=3D450 noShade>

<TABLE cellSpacing=3D2 cellPadding=3D2 width=3D450>
  <TBODY>
  <TR>
    <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
      style=3D"TEXT-DECORATION: none" =
href=3D"http://ard.bmjjournals.com/"=20
      target=3D_top><FONT face=3Darial,helvetica color=3D#ffffff=20
      size=3D-2>HOME</FONT></A></TD>
    <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
      style=3D"TEXT-DECORATION: none" =
href=3D"http://ard.bmjjournals.com/help/"=20
      target=3D_top><FONT face=3Darial,helvetica color=3D#ffffff=20
      size=3D-2>HELP</FONT></A></FONT></TD>
    <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
      style=3D"TEXT-DECORATION: none"=20
      href=3D"http://ard.bmjjournals.com/cgi/feedback" =
target=3D_top><FONT=20
      face=3Darial,helvetica color=3D#ffffff =
size=3D-2>FEEDBACK</FONT></A></TD>
    <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
      style=3D"TEXT-DECORATION: none"=20
      href=3D"http://ard.bmjjournals.com/subscriptions/" =
target=3D_top><FONT=20
      face=3Darial,helvetica color=3D#ffffff =
size=3D-2>SUBSCRIPTIONS</FONT></A></TD>
    <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
      style=3D"TEXT-DECORATION: none"=20
      href=3D"http://ard.bmjjournals.com/contents-by-date.0.shtml"=20
      target=3D_top><FONT face=3Darial,helvetica color=3D#ffffff=20
      size=3D-2>ARCHIVE</FONT></A></TD>
    <TD vAlign=3Dtop noWrap align=3Dmiddle bgColor=3D#9a1149><A=20
      style=3D"TEXT-DECORATION: none" =
href=3D"http://ard.bmjjournals.com/search.dtl"=20
      target=3D_top><FONT face=3Darial,helvetica color=3D#ffffff=20
      size=3D-2>SEARCH</FONT></A></TD>
    <TD noWrap width=3D75></TD></TR></TBODY></TABLE><FONT =
size=3D-1><STRONG><A=20
href=3D"http://ard.bmjjournals.com/misc/terms.shtml" =
target=3D_top>Copyright =A9 2003=20
BMJ Publishing Group Ltd &amp; European League Against=20
Rheumatism.</A></STRONG></FONT> </FONT></FONT></BODY></HTML>

------=_NextPart_000_007F_01C3BCA0.B96D1970
Content-Type: image/gif
Content-Transfer-Encoding: base64
Content-Location: http://ard.bmjjournals.com/icons/banner/title.gif
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------=_NextPart_000_007F_01C3BCA0.B96D1970
Content-Type: image/gif
Content-Transfer-Encoding: base64
Content-Location: http://ard.bmjjournals.com/adgifs/1045585937.gif
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------=_NextPart_000_007F_01C3BCA0.B96D1970
Content-Type: image/gif
Content-Transfer-Encoding: base64
Content-Location: http://ard.bmjjournals.com/icons/spacer.gif

R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAQAICRAEAOw==

------=_NextPart_000_007F_01C3BCA0.B96D1970--
